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Kann ich mir vorstellen du bist ja auch ne Schlafmütze.Welche sind das? Mir sind diese Stoffe nicht bekannt.
ALC-0159
Catalog number: N-2010
Molecular Formula: (C2H4O)nC31H63NO2
MW: ~2330
CAS: 1849616-42-7
Alternative Names:
Solubility: Chloroform (>10mg/mL), Ethanol (>10mg/mL)
Storage and Handling: Store dry at -20 oC. Stock solutions should be stored frozen (-20 oC or below).
Background: ALC-0159 is a PEGylated lipid which has been used to form lipid nanoparticles for delivery
of RNA. ALC-0159 is one of the components in the BNT162b2 vaccine against SARS-CoV-2 in addition to
ALC-0315, DSPC, and cholesterol. This product is for research use only and not for human use.
References: 1) R. Tenchov, R. Bird, A. E. Curtze, Q. Zhou (2021) “Lipid Nanoparticles—From Liposomes to mRNA
Vaccine Delivery, a Landscape of Research Diversity and Advancement” ACS Nano, DOI: 10.1021/acsnano.1c04996.
2) K.H. Moss, P. Popova, et al. (2019) “Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides” Mol.
Pharmaceutics 16, 2265–2277, DOI: 10.1021/acs.molpharmaceut.8b01290.
3) Y. Duan, A. Dhar, et al. (2020) “A brief review on solid lipid nanoparticles: part and parcel of contemporary drug
delivery systems” RSC Adv.,10, 26777-26791.
▶ ALC-0315: (4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate)
▶ ALC-0159: 2[(polyethylene glycol)-2000]-N,N-ditetradecylacetamide
beide Stoffe sicht nur zu Forschungszwecken zugelassen.
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